Anks1a regulates COPII-mediated anterograde transport of receptor tyrosine kinases critical for tumorigenesis

Haeryung Lee; Hyuna Noh; Jiyoung Mun; Changkyu Gu; Sanja Sever; Soochul Park

doi:10.1038/ncomms12799

Nature Communications (Sep 2016)

Anks1a regulates COPII-mediated anterograde transport of receptor tyrosine kinases critical for tumorigenesis

Haeryung Lee,
Hyuna Noh,
Jiyoung Mun,
Changkyu Gu,
Sanja Sever,
Soochul Park

Affiliations

Haeryung Lee: Department of Biological Science, Sookmyung Women’s University
Hyuna Noh: Department of Biological Science, Sookmyung Women’s University
Jiyoung Mun: Department of Biomedical Laboratory Science, College of Health Science, Eulji University
Changkyu Gu: Division of Nephrology, Massachusetts General Hospital
Sanja Sever: Division of Nephrology, Massachusetts General Hospital
Soochul Park: Department of Biological Science, Sookmyung Women’s University

DOI: https://doi.org/10.1038/ncomms12799
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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EphA2/ErbB2 complex is important in promoting breast cancer but the mechanism by which these receptor tyrosine kinases are exported from the endoplasmic reticulum is unknown. Here the authors show that Anks1a acts as a cargo adaptor in sorting EphA2 into COPII vesicles, thus modulating the surface level of EphA2.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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