ApmA Is a Unique Aminoglycoside Antibiotic Acetyltransferase That Inactivates Apramycin
Emily Bordeleau,
Peter J. Stogios,
Elena Evdokimova,
Kalinka Koteva,
Alexei Savchenko,
Gerard D. Wright
Affiliations
Emily Bordeleau
David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada
Peter J. Stogios
Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada
Elena Evdokimova
Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada
Kalinka Koteva
David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada
David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada
Apramycin is an aminoglycoside antibiotic that has been traditionally used in veterinary medicine. Recently, it has become an attractive candidate to repurpose in the fight against multidrug-resistant pathogens prioritized by the World Health Organization.
