Diseases (Oct 2022)

Atypical Viral Infections in Gastroenterology

  • Neira Crnčević,
  • Zijah Rifatbegović,
  • Mirsada Hukić,
  • Sara Deumić,
  • Emina Pramenković,
  • Amir Selimagić,
  • Ismet Gavrankapetanović,
  • Monia Avdić

DOI
https://doi.org/10.3390/diseases10040087
Journal volume & issue
Vol. 10, no. 4
p. 87

Abstract

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Enteric viruses are commonly found obligate parasites in the gastrointestinal (GI) tract. These viruses usually follow a fecal-oral route of transmission and are characterized by their extraordinary stability as well as resistance in high-stress environments. Most of them cause similar symptoms including vomiting, diarrhea, and abdominal pain. In order to come in contract with mucosal surfaces, these viruses need to pass the three main lines of defense: mucus layer, innate immune defenses, and adaptive immune defenses. The following atypical gastrointestinal infections are discussed: SARS-CoV2, hantavirus, herpes simplex virus I, cytomegalovirus, and calicivirus. Dysbiosis represents any modification to the makeup of resident commensal communities from those found in healthy individuals and can cause a patient to become more susceptible to bacterial and viral infections. The interaction between bacteria, viruses, and host physiology is still not completely understood. However, with growing research on viral infections, dysbiosis, and new methods of detection, we are getting closer to understanding the nature of these viruses, their typical and atypical characteristics, long-term effects, and mechanisms of action in different organ systems.

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