The morpho-functional features of the left ventricular myocardium and common carotid arteries in children with cystic fibrosis

Abstract

Background. The features of the morpho-functional state of the left ventricular myocardium and common carotid arteries were studied according to echocardiography in children with cystic fibrosis. Materials and methods. 72 children with cystic fibrosis were examined. To determine the preclinical stage of left ventricular diastolic dysfunction, a functional compliance index (FCI) was determined by the method of A.N. Rosenbaum and V.T. Koval (2010). Results. The results of the study showed the development of left ventricular myocardium remodeling in 58 % of patients with cystic fibrosis, among the variants of which eccentric hypertrophy predominated. The revealed changes increased with an increase in the severity of the course of the disease. The analysis of diastolic function of the left ventricle by standard method in the group of patients with cystic fibrosis did not reveal any significant differences from the parameters of the control group. The FCI calculation showed that in 37.5 % of children with cystic fibrosis, which indicated the formation of left ventricular diastolic dysfunction, which progressed in the course of the disease, it decreased with respect to the values of the control group. The most pronounced changes in FCI were found with concentric left ventricular myocardial hypertrophy and with severe disease. Conclusions. The identified morpho-functional rearrangement of the left heart occurred against the background of remodeling and hemodynamic changes at the level of the common carotid artery in children with cystic fibrosis.

Keywords

• cystic fibrosis
• left ventricular myocardium remodeling
• left ventricular diastolic dysfunction
• common carotid artery
• children