Journal of Pharmacopuncture (Mar 2021)

Biological and Therapeutic Effects of Troxerutin: Molecular Signaling Pathways Come into View

  • Zahra Ahmadi,
  • Reza Mohammadinejad,
  • Sahar Roomiani,
  • Elham Ghasemipour Afshar,
  • Milad Ashrafizadeh

DOI
https://doi.org/10.3831/KPI.2021.24.1.1
Journal volume & issue
Vol. 24, no. 1
pp. 1 – 13

Abstract

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Flavonoids consist a wide range of naturally occurring compounds which are exclusively found in different fruits and vegetables. These medicinal herbs have a number of favour-able biological and therapeutic activities such as antioxidant, neuroprotective, renoprotec-tive, anti-inflammatory, anti-diabetic and anti-tumor. Troxerutin, also known as vitamin P4, is a naturally occurring flavonoid which is isolated from tea, coffee and cereal grains as well as vegetables. It has a variety of valuable pharmacological and therapeutic activities including antioxidant, anti-inflammatory, anti-diabetic and anti-tumor. These pharmaco-logical impacts have been demonstrated in in vitro and in vivo studies. Also, clinical trials have revealed the efficacy of troxerutin for management of phlebocholosis and hemor-rhoidal diseases. In the present review, we focus on the therapeutic effects and biological activities of troxerutin as well as its molecular signaling pathways.

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