Organocatalytic atroposelective synthesis of axially chiral styrenes

Sheng-Cai Zheng; San Wu; Qinghai Zhou; Lung Wa Chung; Liu Ye; Bin Tan

doi:10.1038/ncomms15238

Nature Communications (May 2017)

Organocatalytic atroposelective synthesis of axially chiral styrenes

Sheng-Cai Zheng,
San Wu,
Qinghai Zhou,
Lung Wa Chung,
Liu Ye,
Bin Tan

Affiliations

Sheng-Cai Zheng: Department of Chemistry, South University of Science and Technology of China
San Wu: Department of Chemistry, South University of Science and Technology of China
Qinghai Zhou: Department of Chemistry, South University of Science and Technology of China
Lung Wa Chung: Department of Chemistry, South University of Science and Technology of China
Liu Ye: Department of Chemistry, South University of Science and Technology of China
Bin Tan: Department of Chemistry, South University of Science and Technology of China

DOI: https://doi.org/10.1038/ncomms15238
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 9

Abstract

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Many methods exist for the atroposelective synthesis of axially chiral biaryls, but axially chiral styrenes are much less explored. Here the authors report an organocatalytic procedure for the synthesis of configurationally stable, axially chiral styrenes with high enantio- and diastereoselectivities.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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