Materials (Feb 2021)

Whither Magnetic Hyperthermia? A Tentative Roadmap

  • Irene Rubia-Rodríguez,
  • Antonio Santana-Otero,
  • Simo Spassov,
  • Etelka Tombácz,
  • Christer Johansson,
  • Patricia De La Presa,
  • Francisco J. Teran,
  • María del Puerto Morales,
  • Sabino Veintemillas-Verdaguer,
  • Nguyen T. K. Thanh,
  • Maximilian O. Besenhard,
  • Claire Wilhelm,
  • Florence Gazeau,
  • Quentin Harmer,
  • Eric Mayes,
  • Bella B. Manshian,
  • Stefaan J. Soenen,
  • Yuanyu Gu,
  • Ángel Millán,
  • Eleni K. Efthimiadou,
  • Jeff Gaudet,
  • Patrick Goodwill,
  • James Mansfield,
  • Uwe Steinhoff,
  • James Wells,
  • Frank Wiekhorst,
  • Daniel Ortega

DOI
https://doi.org/10.3390/ma14040706
Journal volume & issue
Vol. 14, no. 4
p. 706

Abstract

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The scientific community has made great efforts in advancing magnetic hyperthermia for the last two decades after going through a sizeable research lapse from its establishment. All the progress made in various topics ranging from nanoparticle synthesis to biocompatibilization and in vivo testing have been seeking to push the forefront towards some new clinical trials. As many, they did not go at the expected pace. Today, fruitful international cooperation and the wisdom gain after a careful analysis of the lessons learned from seminal clinical trials allow us to have a future with better guarantees for a more definitive takeoff of this genuine nanotherapy against cancer. Deliberately giving prominence to a number of critical aspects, this opinion review offers a blend of state-of-the-art hints and glimpses into the future of the therapy, considering the expected evolution of science and technology behind magnetic hyperthermia.

Keywords