FS-7 inhibits MGC-803 cells growth in vitro and in vivo via down-regulating glycolysis

Xiangping Deng; Zhongli Li; Runde Xiong; Juan Liu; Renbo Liu; Junmei Peng; Yanming Chen; Xiaoyong Lei; Xuan Cao; Xing Zheng; Zhizhong Xie; Guotao Tang

Biomedicine & Pharmacotherapy (Jan 2019)

FS-7 inhibits MGC-803 cells growth in vitro and in vivo via down-regulating glycolysis

Xiangping Deng,
Zhongli Li,
Runde Xiong,
Juan Liu,
Renbo Liu,
Junmei Peng,
Yanming Chen,
Xiaoyong Lei,
Xuan Cao,
Xing Zheng,
Zhizhong Xie,
Guotao Tang

Affiliations

Xiangping Deng: Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target, New Drug Study, University of South China, Hengyang, China
Zhongli Li: Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target, New Drug Study, University of South China, Hengyang, China
Runde Xiong: Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target, New Drug Study, University of South China, Hengyang, China
Juan Liu: Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target, New Drug Study, University of South China, Hengyang, China
Renbo Liu: Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target, New Drug Study, University of South China, Hengyang, China
Junmei Peng: Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target, New Drug Study, University of South China, Hengyang, China
Yanming Chen: Jiuzhitang Co. Ltd, Changsha, China
Xiaoyong Lei: Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target, New Drug Study, University of South China, Hengyang, China
Xuan Cao: Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target, New Drug Study, University of South China, Hengyang, China
Xing Zheng: Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target, New Drug Study, University of South China, Hengyang, China
Zhizhong Xie: Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target, New Drug Study, University of South China, Hengyang, China; Corresponding authors at: Institute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan, 421001, China.
Guotao Tang: Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target, New Drug Study, University of South China, Hengyang, China; Corresponding authors at: Institute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan, 421001, China.

Journal volume & issue: Vol. 109
pp. 1659 – 1669

Abstract

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In this study, we investigated the anticancer effects of FS-7, a flavonoid salicylate derivative, in human gastric carcinoma MGC-803 cell line and studied its preliminary anticancer effects. FS-7 displayed greater in vitro cytotoxicity against MGC-803 cell line compared with 5-Fu and had a certain extent of selectivity to cancer cells. The flow cytometry analysis revealed that FS-7 induced apoptosis MGC-803 cells and mainly caused cells arrest in the G2/M phase in a concentration-dependent manner. Additionally, FS-7 inhibited the colony formation and cell migration in a concentration-dependent manner. Notably, FS-7 noticeably down-regulated glycolysis-related protein HIF-1α, HK-II and PFKP expression in a concentration-dependent manner, possibly causing glycolysis inhibition. Importantly, compared with 5-Fu, FS-7 showed better anticancer activity in the MGC-803 xenograft murine tumor models. Collectively, the present study provided a promising anticancer drug candidate for gastric cancer therapy.

Published in Biomedicine & Pharmacotherapy

ISSN: 0753-3322 (Print); 1950-6007 (Online)
Publisher: Elsevier
Country of publisher: France
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://www.journals.elsevier.com/biomedicine-and-pharmacotherapy

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