L-5-hydroxytryptophan promotes antitumor immunity by inhibiting PD-L1 inducible expression

• Yuanyuan Zhang,
• Jing Huang,
• Bing Li,
• Jin Yu,
• Xiaobo Wang,
• Shiyu Shen,
• Ruina Wang,
• Hongru Tao,
• Junchi Hu,
• Hualiang Jiang,
• Kaixian Chen,
• Cheng Luo,
• Yongjun Dang

Affiliations

Yuanyuan Zhang

Department of Rehabilitation Medicine, Tianjin Medical University, Tianjin, China

Jing Huang

Aff180 grid.416466.7Department of Infectious Diseases and Hepatology UnitNanfang Hospital Guangzhou Guangdong People’s Republic of China

Bing Li

Guangdong Women and Children Hospital, Guangzhou, Guangdong, China

Jin Yu

1 Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, Shanghai, China

Xiaobo Wang

4 Department of Hepatobiliary and Pancreas Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Guangxi, China

Shiyu Shen

Department of Integrative Medicine and Neurobiology, State Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences, Institutes of Brain Science, Brain Science Collaborative Innovation Center, Shanghai Medical College of Fudan University, Shanghai, China

Ruina Wang

Key Laboratory of Metabolism and Molecular Medicine, The Ministry of Education, Department of Biochemistry and Molecular Biology, Fudan University School of Basic Medical Sciences, Shanghai, China

Hongru Tao

Drug Discovery and Design Center, The Center for Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai, China

Junchi Hu

Center for Novel Target and Therapeutic Intervention, Chongqing Medical University, Chongqing, China

Hualiang Jiang

Drug Discovery and Design Center, The Center for Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai, China

Kaixian Chen

Drug Discovery and Design Center, The Center for Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai, China

Cheng Luo

Drug Discovery and Design Center, The Center for Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai, China

Yongjun Dang

Key Laboratory of Metabolism and Molecular Medicine, The Ministry of Education, Department of Biochemistry and Molecular Biology, Fudan University School of Basic Medical Sciences, Shanghai, China