Initial Muscle Quality Affects Individual Responsiveness of Interleukin-6 and Creatine Kinase following Acute Eccentric Exercise in Sedentary Obese Older Women
Ivo Vieira de Sousa Neto,
Dahan da Cunha Nascimento,
Jonato Prestes,
Eduardo Fernandes da Fonseca,
Rodrigo Souza Celes,
Nicholas Rolnick,
Yuri Gustavo de Sousa Barbalho,
Alessandro de Oliveira Silva,
Marina Morato Stival,
Luciano Ramos de Lima,
Silvana Schwerz Funghetto
Affiliations
Ivo Vieira de Sousa Neto
Laboratory of Molecular Analysis, Faculty of Ceilândia, Universidade de Brasília, Brasilia 70910-900, Brazil
Dahan da Cunha Nascimento
Graduate Program of Physical Education, Catholic University of Brasilia, Brasilia 70910-900, Brazil
Jonato Prestes
Graduate Program of Physical Education, Catholic University of Brasilia, Brasilia 70910-900, Brazil
Eduardo Fernandes da Fonseca
Graduate Program of Physical Education, Catholic University of Brasilia, Brasilia 70910-900, Brazil
Rodrigo Souza Celes
Graduate Program of Physical Education, Catholic University of Brasilia, Brasilia 70910-900, Brazil
Nicholas Rolnick
The Human Performance Mechanic, Lehman College, New York, NY 10468, USA
Yuri Gustavo de Sousa Barbalho
Graduate Program of Sciences and Technology of Health, Faculty of Ceilândia, Universidade de Brasília, Brasilia 70910-900, Brazil
Alessandro de Oliveira Silva
Faculty of Physical Education and Medicine, Center University of Brasilia, Brasilia 70910-900, Brazil
Marina Morato Stival
Graduate Program of Sciences and Technology of Health, Faculty of Ceilândia, Universidade de Brasília, Brasilia 70910-900, Brazil
Luciano Ramos de Lima
Department of Nursing, Faculty of Ceilândia, Universidade de Brasília, Brasilia 70910-900, Brazil
Silvana Schwerz Funghetto
Graduate Program of Sciences and Technology of Health, Faculty of Ceilândia, Universidade de Brasília, Brasilia 70910-900, Brazil
This study aimed to evaluate the time course and responsiveness of plasma interleukin-6 (IL-6) and creatine kinase (CK) levels following acute eccentric resistance exercise in sedentary obese older women with a different muscle quality index (MQI). Eighty-eight participants (69.4 ± 6.06 years) completed an acute eccentric resistance exercise (7 sets of 10 repetitions at 110% of 10-repetition maximum with 3 min rest interval). Participants were divided into two groups: high or low MQI according to 50th percentile cut-off. The responsiveness was based on minimal clinical important difference. There were no differences between groups and time on IL-6 and CK levels (p > 0.05). However, the high MQI group displayed a lower proportion of low responders (1 for laboratory and 2 for field-based vs. 5 and 4) and a higher proportion of high responders for IL-6 (7 for laboratory and 6 for field-based vs. 4 and 5) compared to low MQI group. In addition, the high MQI group showed a higher proportion of high responders for CK (11 for laboratory and 9 for field-based vs. 6 and 6) compared to low MQI. A prior MQI screening can provide feedback to understand the magnitude response. Individual responsiveness should be taken into consideration for maximizing eccentric exercise prescription.
