Nature Communications (Sep 2017)

IL-12p35 induces expansion of IL-10 and IL-35-expressing regulatory B cells and ameliorates autoimmune disease

  • Ivy M. Dambuza,
  • Chang He,
  • Jin Kyeong Choi,
  • Cheng-Rong Yu,
  • Renxi Wang,
  • Mary J. Mattapallil,
  • Paul T. Wingfield,
  • Rachel R. Caspi,
  • Charles E. Egwuagu

DOI
https://doi.org/10.1038/s41467-017-00838-4
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 12

Abstract

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IL-12p35 is common to IL-35 and IL-12, which have opposing effects on inflammation. Here the authors show that the IL-12p35 subunit induces regulatory B cells and can be used therapeutically to limit autoimmune uveitis in mice.