Nature Communications (Jan 2019)
The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells
- Esperanza Perucha,
- Rossella Melchiotti,
- Jack A Bibby,
- Wing Wu,
- Klaus Stensgaard Frederiksen,
- Ceri A. Roberts,
- Zoe Hall,
- Gaelle LeFriec,
- Kevin A. Robertson,
- Paul Lavender,
- Jens Gammeltoft Gerwien,
- Leonie S. Taams,
- Julian L. Griffin,
- Emanuele de Rinaldis,
- Lisa G. M. van Baarsen,
- Claudia Kemper,
- Peter Ghazal,
- Andrew P. Cope
Affiliations
- Esperanza Perucha
- Academic Department of Rheumatology, King’s College London
- Rossella Melchiotti
- National Institute for Health Research Biomedical Research Centre, Guy’s and St Thomas’ NHS Foundation Trust and King’s College London
- Jack A Bibby
- Academic Department of Rheumatology, King’s College London
- Wing Wu
- Academic Department of Rheumatology, King’s College London
- Klaus Stensgaard Frederiksen
- Global Drug Discovery, Novo Nordisk A/S
- Ceri A. Roberts
- Department of Inflammation Biology, School of Immunology and Microbial Sciences, Centre for Inflammation Biology and Cancer Immunology, King’s College London
- Zoe Hall
- Department of Biochemistry and the Cambridge Systems Biology Centre, University of Cambridge
- Gaelle LeFriec
- MRC Centre for Transplantation, King’s College London
- Kevin A. Robertson
- Division of Infection and Pathway Medicine, University of Edinburgh
- Paul Lavender
- School of Immunology and Microbial Sciences, King’s College London
- Jens Gammeltoft Gerwien
- Global Drug Discovery, Novo Nordisk A/S
- Leonie S. Taams
- Department of Inflammation Biology, School of Immunology and Microbial Sciences, Centre for Inflammation Biology and Cancer Immunology, King’s College London
- Julian L. Griffin
- Department of Biochemistry and the Cambridge Systems Biology Centre, University of Cambridge
- Emanuele de Rinaldis
- National Institute for Health Research Biomedical Research Centre, Guy’s and St Thomas’ NHS Foundation Trust and King’s College London
- Lisa G. M. van Baarsen
- Amsterdam Rheumatology and immunology Center (ARC), Department of Rheumatology and Clinical Immunology, Amsterdam UMC, University of Amsterdam
- Claudia Kemper
- MRC Centre for Transplantation, King’s College London
- Peter Ghazal
- Division of Infection and Pathway Medicine, University of Edinburgh
- Andrew P. Cope
- Academic Department of Rheumatology, King’s College London
- DOI
- https://doi.org/10.1038/s41467-019-08332-9
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
Metabolic pathways are increasingly recognized as crucial determinants of T cell function. Here the authors show that the balance between IFNγ and IL-10 production in human CD4 T cells is modulated by the cholesterol biosynthetic pathway.
