Polyoxometalates (Sep 2024)

Superchaotropic polyoxometalates as membrane carriers

  • Aleksandar Kondinski

Journal volume & issue
Vol. 3, no. 3
p. 9140058


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In the realm of pharmaceutical drug delivery and bioimaging, the innovative design of membrane transporters is crucial. This highlight article focuses on the recent collaborative study published in Advanced Materials (DOI: 10.1002/adma.202309219) between the research groups of Nau and Rompel, investigating Keggin and Anderson-Evans type polyoxometalates (POMs) as superchaotropic carriers in both model membranes and live cells under physiological conditions. The Kegginoidal POM carriers, at concentrations as low as 5 µM, successfully transport various oligo- and polypeptides, surpassing the performance of boron clusters (DOI: 10.1038/s41586-022-04413-w).