Nature Communications (Dec 2022)

Phosphoproteomic analysis of neoadjuvant breast cancer suggests that increased sensitivity to paclitaxel is driven by CDK4 and filamin A

  • S. Mouron,
  • M. J. Bueno,
  • A. Lluch,
  • L. Manso,
  • I. Calvo,
  • J. Cortes,
  • J. A. Garcia-Saenz,
  • M. Gil-Gil,
  • N. Martinez-Janez,
  • J. V. Apala,
  • E. Caleiras,
  • Pilar Ximénez-Embún,
  • J. Muñoz,
  • L. Gonzalez-Cortijo,
  • R. Murillo,
  • R. Sánchez-Bayona,
  • J. M. Cejalvo,
  • G. Gómez-López,
  • C. Fustero-Torre,
  • S. Sabroso-Lasa,
  • N. Malats,
  • M. Martinez,
  • A. Moreno,
  • D. Megias,
  • M. Malumbres,
  • R. Colomer,
  • M. Quintela-Fandino

DOI
https://doi.org/10.1038/s41467-022-35065-z
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 18

Abstract

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Phosphoproteomics is a promising tool for identifying biomarkers of treatment response in cancer. Here, the authors analyse proteomics profiling of HER2-negative female breast cancer patients and identify potential predictors of paclitaxel response.