Evaluation of intra-abdominal pressure as an early marker of diuretic response in patients with cardiorenal syndrome

Abstract

Introduction: Renal dysfunction and heart failure (HF) are closely intermingled, even though their pathophysiology is not fully understood. Recently, abdominal congestion, through an increase of intra-abdominal pressure (IAP), has been proposed as a novel and important factor in cardiorenal interactions. In this study, we postulated that IAP is linked to renal function and diuretic response in acute heart failure (AHF) patients. Objectives: The objectives of this study were to analyze whether IAP variations in AHF patients are associated with changes in renal function and diuretic response during the first 72 h of admission. Methods: The prospective, observational, and single-center cohort study in AHF patients admitted at the Internal Medicine department. Multiparametric congestion assessment, including X-rays, point of care ultrasoung, serum biomarkers and IAP, will be performed during the first 72 h. Conclusions: We aim to broaden the knowledge about IAP changes and its correlation with renal function and diuretic response in patients admitted with AHF.

Keywords

• Intra-abdominal pressure. Cardiorenal syndrome. Congestion. Diuretic response.