Nature Communications (May 2020)
Long non-coding RNA RAMS11 promotes metastatic colorectal cancer progression
- Jessica M. Silva-Fisher,
- Ha X. Dang,
- Nicole M. White,
- Matthew S. Strand,
- Bradley A. Krasnick,
- Emily B. Rozycki,
- Gejae G. L. Jeffers,
- Julie G. Grossman,
- Maureen K. Highkin,
- Cynthia Tang,
- Christopher R. Cabanski,
- Abdallah Eteleeb,
- Jacqueline Mudd,
- S. Peter Goedegebuure,
- Jingqin Luo,
- Elaine R. Mardis,
- Richard K. Wilson,
- Timothy J. Ley,
- Albert C. Lockhart,
- Ryan C. Fields,
- Christopher A. Maher
Affiliations
- Jessica M. Silva-Fisher
- Department of Internal Medicine, Washington University School of Medicine
- Ha X. Dang
- Department of Internal Medicine, Washington University School of Medicine
- Nicole M. White
- Department of Internal Medicine, Washington University School of Medicine
- Matthew S. Strand
- Department of Surgery, Washington University School of Medicine
- Bradley A. Krasnick
- Department of Surgery, Washington University School of Medicine
- Emily B. Rozycki
- Department of Internal Medicine, Washington University School of Medicine
- Gejae G. L. Jeffers
- Department of Internal Medicine, Washington University School of Medicine
- Julie G. Grossman
- Department of Surgery, Washington University School of Medicine
- Maureen K. Highkin
- Department of Internal Medicine, Washington University School of Medicine
- Cynthia Tang
- Department of Internal Medicine, Washington University School of Medicine
- Christopher R. Cabanski
- Parker Institute for Cancer Immunotherapy
- Abdallah Eteleeb
- Department of Internal Medicine, Washington University School of Medicine
- Jacqueline Mudd
- Department of Surgery, Washington University School of Medicine
- S. Peter Goedegebuure
- Department of Surgery, Washington University School of Medicine
- Jingqin Luo
- Alvin J. Siteman Cancer Center, Washington University School of Medicine
- Elaine R. Mardis
- Institute for Genomic Medicine, Nationwide Children’s Hospital
- Richard K. Wilson
- Institute for Genomic Medicine, Nationwide Children’s Hospital
- Timothy J. Ley
- Department of Internal Medicine, Washington University School of Medicine
- Albert C. Lockhart
- Department of Medicine, University of Miami
- Ryan C. Fields
- Alvin J. Siteman Cancer Center, Washington University School of Medicine
- Christopher A. Maher
- Department of Internal Medicine, Washington University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-020-15547-8
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
The role of long non-coding RNAs (lncRNAs) in metastatic colorectal cancer (mCRC) and treatment resistance is unclear. Here, the authors use transcriptome sequencing of matched normal, primary, and metastatic CRC tissues to discover and validate that lncRNA RAMS11 promotes metastasis and resistance to topoisomerase inhibitors in mCRC.
