Asian-Australasian Journal of Animal Sciences (Oct 2013)

The Possibility of as a Candidate Gene for Teat Numbers in Pigs

  • S. Jin,
  • J. B. Lee,
  • K. Kang,
  • C. K. Yoo,
  • B. M. Kim,
  • H. B. Park,
  • H. T. Lim,
  • I. C. Cho,
  • D. Maharani,
  • J. H. Lee

DOI
https://doi.org/10.5713/ajas.2013.13140
Journal volume & issue
Vol. 26, no. 10
pp. 1374 – 1378

Abstract

Read online

Based on a quantitative traits locus (QTL) study using a F2 intercross between Landrace and Korean native pigs, a significant QTL affecting teat numbers in SSC7 was identified. The strong positional candidate gene, TBC1D21, was selected due to its biological function for epithelial mesenchymal cell development. Sequence analysis revealed six single nucleotide polymorphisms (SNPs) in the TBC1D21 gene. Among these, two SNP markers, one silent mutation (SNP01) for g.13,050A>G and one missense mutation (SNP04) for c.829A>T (S277C), were genotyped and they showed significant associations with teat number traits (p value = 6.38E-05 for SNP01 and p value = 1.06E-07 for SNP04 with total teat numbers). Further functional validation of these SNPs could give valuable information for understanding the teat number variation in pigs.

Keywords