Инфекция и иммунитет (Jul 2014)

THE CHANGES OF OF CELLULAR IMMUNITY PARAMETERS IN PATIENTS WITH PREINVASIVE AND MICROINVASIVE CERVICAL CANCER BEFORE AND AFTER TREATMENT

  • P. I. Kovchur,
  • E. V. Bahidze,
  • A. V. Yastrebova

DOI
https://doi.org/10.15789/2220-7619-2014-2-173-180
Journal volume & issue
Vol. 4, no. 2
pp. 173 – 180

Abstract

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Abstract. The comparative study of immunocompetent cells’ phenotype was performed in patients with the preinvasive and microinvasive cervical cancer before and after the treatment. Besides, the study of importance of selected cellular immunity indices as a predicitive factors of effective surgical treatment in a combination with immunotherapy (the study group) in comparison with a surgical treatment only (the control group) have been conducted. The true numerical normalization of subpopulation composition of peripheral blood lymphocyte has been determined including the expression level of suppressor lymphocytes molecular markers (FOXP3 и TGF-β1) and the expression level of CD95-marker in a study group in comparison with a control group. Moreover, true decrease of HPV (human papillomavirus) — positive patients (1.7%) and the absence of E7 oncoprotein in the study group have been discovered.

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