Massive Splenomegaly

Abstract

Massive splenomegaly, defined as length spleen greater than 20 cm, is a relatively rare entity with a broad differential. Primary splenomegaly occurs in the setting of leukemias and lymphomas, whereas secondary splenomegaly is more common and carries a broad differential. We present a case of massive splenomegaly with an approach to differential diagnoses and brief discussion of splenic marginal zone lymphoma.