Data on COA-Cl administration to the APP/PS2 double-transgenic mouse model of Alzheimer׳s disease: Improved hippocampus-dependent learning and unchanged spontaneous physical activity
Yasushi Kishimoto,
Ikuko Tsukamoto,
Atsuko Nishigawa,
Akiko Nishimoto,
Yutaka Kirino,
Yoshihisa Kato,
Ryoji Konishi,
Tokumi Maruyama,
Norikazu Sakakibara
Affiliations
Yasushi Kishimoto
Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Japan; Corresponding author.
Ikuko Tsukamoto
Department of Pharmaco-Bio-Informatics, Faculty of Medicine, Kagawa University, Japan
Atsuko Nishigawa
Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Japan
Akiko Nishimoto
Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Japan
Yutaka Kirino
Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Japan
Yoshihisa Kato
Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Japan
Ryoji Konishi
Department of Pharmaco-Bio-Informatics, Faculty of Medicine, Kagawa University, Japan
Tokumi Maruyama
Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Japan
Norikazu Sakakibara
Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Japan
We herein present behavioral data regarding whether COA-Cl, a novel adenosine-like nucleic acid analog that promotes angiogenesis and features neuroprotective roles, improves cognitive and behavioral deficits in a murine model for Alzheimer׳s disease (AD). COA-Cl induced significant spatial memory improvement in the amyloid precursor protein/presenilin 2 double-transgenic mouse model of AD (PS2Tg2576 mice). Correspondingly, non-spatial novel object cognition test performance also significantly improved in COA-Cl-treated PS2Tg2576 mice; however, these mice demonstrated no significant changes in physical activity or motor performance. COA-Cl did not change the spontaneous activities and cognitive ability in the wild-type mice. Keywords: Alzheimer׳s disease, Angiogenesis, Novel object cognition test, Spatial memory, Spontaneous physical activity, Non-spatial memory
