Nature Communications (Jul 2017)
AIM1 is an actin-binding protein that suppresses cell migration and micrometastatic dissemination
- Michael C. Haffner,
- David M. Esopi,
- Alcides Chaux,
- Meltem Gürel,
- Susmita Ghosh,
- Ajay M. Vaghasia,
- Harrison Tsai,
- Kunhwa Kim,
- Nicole Castagna,
- Hong Lam,
- Jessica Hicks,
- Nicolas Wyhs,
- Debika Biswal Shinohara,
- Paula J. Hurley,
- Brian W. Simons,
- Edward M. Schaeffer,
- Tamara L. Lotan,
- William B. Isaacs,
- George J. Netto,
- Angelo M. De Marzo,
- William G. Nelson,
- Steven S. An,
- Srinivasan Yegnasubramanian
Affiliations
- Michael C. Haffner
- Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University
- David M. Esopi
- Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University
- Alcides Chaux
- Department of Pathology, Johns Hopkins University
- Meltem Gürel
- Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University
- Susmita Ghosh
- Department of Pathology, Johns Hopkins University
- Ajay M. Vaghasia
- Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University
- Harrison Tsai
- Department of Pathology, Johns Hopkins University
- Kunhwa Kim
- Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University
- Nicole Castagna
- Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University
- Hong Lam
- Department of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University
- Jessica Hicks
- Department of Pathology, Johns Hopkins University
- Nicolas Wyhs
- Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University
- Debika Biswal Shinohara
- Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University
- Paula J. Hurley
- Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University
- Brian W. Simons
- Brady Urological Institute, School of Medicine, Johns Hopkins University
- Edward M. Schaeffer
- Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University
- Tamara L. Lotan
- Department of Pathology, Johns Hopkins University
- William B. Isaacs
- Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University
- George J. Netto
- Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University
- Angelo M. De Marzo
- Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University
- William G. Nelson
- Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University
- Steven S. An
- Department of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University
- Srinivasan Yegnasubramanian
- Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University
- DOI
- https://doi.org/10.1038/s41467-017-00084-8
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 17
Abstract
Invasion of malignant cells involves changes in cytoskeleton dynamics. Here the authors identify absent in melanoma 1 as an actin binding protein and show that it regulates cytoskeletal remodeling and cell migration in prostate epithelial cells, acting as a metastatic suppressor in cancer cells.
