EFFICIENCY AND ADHERENCE TO THE THERAPY FOR HIV INFECTION IN THE REPUBLIC OF TAJIKISTAN

Abstract

Objective: Integrated assessment of effectiveness of the highly active antiretroviral therapy (HAART) and adherence to the therapy in HIVinfected patients with clinical stages of 3 and 4. Methods: Forty two patients receiving HAART underwent investigation. The assessment of adherence was conducted on the base of simplified questionnaire to evaluate the precision of the followed regime of taking drugs, method and counting the consumed pills. Virological, immunological and clinical criterias were used to monitor the efficacy of the therapy Results: According to the survey results and counted pills, a high adherence was observed in 30 (71.4%) of patients, medium in 4 (9.5%), low in 8 (19.0%). In analyze of reasons with poor adherence to the therapy are: in first place the consumption of addictive drugs, and the second: the development of side effects from HAART, which was connected with the resumption of narcotic substance and the late onset of specific therapy of HIV infectious. The efficacy of conducted antiretroviral therapy in 32 (76.2%) HIV-infected patients was observed in immunological, virological and clinical settings. The discordance between the virological and immunological responses was observed in 5 (11.9%) of patients, where immunological efficacy was not achieved in 2 patients, and virological failure was detected in 3 patients. The therapy was not effective in 5 (11.9%) of patients from the group with low level of adherence. Conclusion: To achieve the desirable result of HAART, it is necessary of high adherence to the therapy and eradication of the negative factors that affects to it.

Keywords

• haart
• effectiveness
• adherence.