Predicting Progression of Kidney Injury Based on Elastography Ultrasound and Radiomics Signatures
Minyan Zhu,
Lumin Tang,
Wenqi Yang,
Yao Xu,
Xiajing Che,
Yin Zhou,
Xinghua Shao,
Wenyan Zhou,
Minfang Zhang,
Guanghan Li,
Min Zheng,
Qin Wang,
Hongli Li,
Shan Mou
Affiliations
Minyan Zhu
Molecular Cell Laboratory for Kidney Disease, Department of Nephrology, Shanghai Peritoneal Dialysis Research Center, Uremia Diagnosis and Treatment Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
Lumin Tang
Molecular Cell Laboratory for Kidney Disease, Department of Nephrology, Shanghai Peritoneal Dialysis Research Center, Uremia Diagnosis and Treatment Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
Wenqi Yang
School of Medicine, Department of Ultrasound, Renji Hospital, Shanghai Jiao Tong University, Shanghai 200127, China
Yao Xu
Molecular Cell Laboratory for Kidney Disease, Department of Nephrology, Shanghai Peritoneal Dialysis Research Center, Uremia Diagnosis and Treatment Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
Xiajing Che
Molecular Cell Laboratory for Kidney Disease, Department of Nephrology, Shanghai Peritoneal Dialysis Research Center, Uremia Diagnosis and Treatment Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
Yin Zhou
Molecular Cell Laboratory for Kidney Disease, Department of Nephrology, Shanghai Peritoneal Dialysis Research Center, Uremia Diagnosis and Treatment Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
Xinghua Shao
Molecular Cell Laboratory for Kidney Disease, Department of Nephrology, Shanghai Peritoneal Dialysis Research Center, Uremia Diagnosis and Treatment Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
Wenyan Zhou
Molecular Cell Laboratory for Kidney Disease, Department of Nephrology, Shanghai Peritoneal Dialysis Research Center, Uremia Diagnosis and Treatment Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
Minfang Zhang
Molecular Cell Laboratory for Kidney Disease, Department of Nephrology, Shanghai Peritoneal Dialysis Research Center, Uremia Diagnosis and Treatment Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
Guanghan Li
China-Japan Friendship Hospital, Department of Ultrasound, Beijing 100029, China
Min Zheng
China-Japan Friendship Hospital, Department of Ultrasound, Beijing 100029, China
Qin Wang
Molecular Cell Laboratory for Kidney Disease, Department of Nephrology, Shanghai Peritoneal Dialysis Research Center, Uremia Diagnosis and Treatment Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
Hongli Li
School of Medicine, Department of Ultrasound, Renji Hospital, Shanghai Jiao Tong University, Shanghai 200127, China
Shan Mou
Molecular Cell Laboratory for Kidney Disease, Department of Nephrology, Shanghai Peritoneal Dialysis Research Center, Uremia Diagnosis and Treatment Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
Background: Shear wave elastography ultrasound (SWE) is an emerging non-invasive candidate for assessing kidney stiffness. However, its prognostic value regarding kidney injury is unclear. Methods: A prospective cohort was created from kidney biopsy patients in our hospital from May 2019 to June 2020. The primary outcome was the initiation of renal replacement therapy or death, while the secondary outcome was eGFR 2. Ultrasound, biochemical, and biopsy examinations were performed on the same day. Radiomics signatures were extracted from the SWE images. Results: In total, 187 patients were included and followed up for 24.57 ± 5.52 months. The median SWE value of the left kidney cortex (L_C_median) is an independent risk factor for kidney prognosis for stage 3 or over (HR 0.890 (0.796–0.994), p p < 0.001). The traditional Cox regression model had a c-index of 0.9051 (0.8460–0.9196), which was no worse than the machine learning models, Support Vector Machine (SVM), SurvivalTree, Random survival forest (RSF), Coxboost, and Deepsurv. Conclusions: SWE can predict kidney injury progression with an improved performance by radiomics and Cox regression modeling.
