Nature Communications (May 2020)
Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response
- Estefanie Dufey,
- José Manuel Bravo-San Pedro,
- Cristian Eggers,
- Matías González-Quiroz,
- Hery Urra,
- Alfredo I. Sagredo,
- Denisse Sepulveda,
- Philippe Pihán,
- Amado Carreras-Sureda,
- Younis Hazari,
- Eduardo A. Sagredo,
- Daniela Gutierrez,
- Cristian Valls,
- Alexandra Papaioannou,
- Diego Acosta-Alvear,
- Gisela Campos,
- Pedro M. Domingos,
- Rémy Pedeux,
- Eric Chevet,
- Alejandra Alvarez,
- Patricio Godoy,
- Peter Walter,
- Alvaro Glavic,
- Guido Kroemer,
- Claudio Hetz
Affiliations
- Estefanie Dufey
- Biomedical Neuroscience Institute (BNI), Faculty of Medicine, University of Chile
- José Manuel Bravo-San Pedro
- Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Inserm U1138, Université de Paris, Sorbonne Université
- Cristian Eggers
- Department of Biology, Faculty of Sciences, University of Chile
- Matías González-Quiroz
- Biomedical Neuroscience Institute (BNI), Faculty of Medicine, University of Chile
- Hery Urra
- Biomedical Neuroscience Institute (BNI), Faculty of Medicine, University of Chile
- Alfredo I. Sagredo
- Biomedical Neuroscience Institute (BNI), Faculty of Medicine, University of Chile
- Denisse Sepulveda
- Biomedical Neuroscience Institute (BNI), Faculty of Medicine, University of Chile
- Philippe Pihán
- Biomedical Neuroscience Institute (BNI), Faculty of Medicine, University of Chile
- Amado Carreras-Sureda
- Biomedical Neuroscience Institute (BNI), Faculty of Medicine, University of Chile
- Younis Hazari
- Biomedical Neuroscience Institute (BNI), Faculty of Medicine, University of Chile
- Eduardo A. Sagredo
- Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Svante Arrheniusväg 20C
- Daniela Gutierrez
- Department of Cell & Molecular Biology, Pontificia Universidad Católica de Chile
- Cristian Valls
- Department of Cell & Molecular Biology, Pontificia Universidad Católica de Chile
- Alexandra Papaioannou
- Proteostasis & Cancer Team, INSERM U1242, University of Rennes 1
- Diego Acosta-Alvear
- Department of Biochemistry and Biophysics, University of California
- Gisela Campos
- IfADo-Leibniz Research Centre for Working Environment and Human Factors at the Technical University Dortmund
- Pedro M. Domingos
- Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Av. da República
- Rémy Pedeux
- Proteostasis & Cancer Team, INSERM U1242, University of Rennes 1
- Eric Chevet
- Proteostasis & Cancer Team, INSERM U1242, University of Rennes 1
- Alejandra Alvarez
- Department of Cell & Molecular Biology, Pontificia Universidad Católica de Chile
- Patricio Godoy
- IfADo-Leibniz Research Centre for Working Environment and Human Factors at the Technical University Dortmund
- Peter Walter
- Department of Biochemistry and Biophysics, University of California
- Alvaro Glavic
- Department of Biology, Faculty of Sciences, University of Chile
- Guido Kroemer
- Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Inserm U1138, Université de Paris, Sorbonne Université
- Claudio Hetz
- Biomedical Neuroscience Institute (BNI), Faculty of Medicine, University of Chile
- DOI
- https://doi.org/10.1038/s41467-020-15694-y
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
IRE1α plays a key role in the unfolded protein response (UPR) by promoting the unconventional splicing of the XBP1 and the selective cleavage of RNAs. Here the authors report that IRE1α is activated upon the DNA damage response and selectively controls the stability of mRNAs to maintain genome integrity.
