Progressive Perceptual-Motor Impairment without Generalized Dementia: A Type of Cortical Degenerative Syndrome

Abstract

A patient developed slowly progressive clumsiness of both upper extremities with associated impainnent of daily activities without loss of muscle strength or abnormal muscle tone. Her sensory function was normal in the primary modalities but was impaired in the discriminative tasks. A single photon emission computed tomography using 123I-iodoamphetamine showed the areas with reduced uptake in the postcentral cortices. Based on the analysis of her motor impairment, we conclude that clumsiness of hands results from higher sensory disturbance.