Abstract Hypertriglyceridemia‐induced acute pancreatitis (HTG‐AP) is the third most common cause of AP after gallstones and alcohol. Supportive measures, intravenous insulin, and plasmapheresis are possible treatment modalities for HTG‐AP; however, definitive guidelines evaluating the best therapeutic approach are not clearly established. We present a rare case of a 42‐year‐old male without known comorbidities who was found to have HTG‐AP. Despite early initiation of intravenous insulin and plasmapheresis and the initial decline in his triglycerides level, his condition was complicated by necrotizing pancreatitis and subsequent multi‐organ failure. Future studies are warranted to evaluate the role of plasmapheresis in HTG‐AP and its efficacy.
