Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells

Charlène Niogret; S. M. Shahjahan Miah; Giorgia Rota; Nicolas P. Fonta; Haiping Wang; Werner Held; Walter Birchmeier; Veronica Sexl; Wentian Yang; Eric Vivier; Ping-Chih Ho; Laurent Brossay; Greta Guarda

doi:10.1038/s41467-019-09431-3

Nature Communications (Mar 2019)

Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells

Charlène Niogret,
S. M. Shahjahan Miah,
Giorgia Rota,
Nicolas P. Fonta,
Haiping Wang,
Werner Held,
Walter Birchmeier,
Veronica Sexl,
Wentian Yang,
Eric Vivier,
Ping-Chih Ho,
Laurent Brossay,
Greta Guarda

Affiliations

Charlène Niogret: Department of Biochemistry, University of Lausanne
S. M. Shahjahan Miah: Department of Molecular Microbiology and Immunology and Graduate Program in Pathobiology, Division of Biology and Medicine, Brown University Alpert Medical School
Giorgia Rota: Department of Biochemistry, University of Lausanne
Nicolas P. Fonta: Department of Biochemistry, University of Lausanne
Haiping Wang: Department of Oncology UNIL CHUV, University of Lausanne
Werner Held: Department of Oncology UNIL CHUV, University of Lausanne
Walter Birchmeier: Max-Delbrueck-Center for Molecular Medicine (MDC) in the Helmholtz Society
Veronica Sexl: Department for Biomedical Sciences, Institute of Pharmacology and Toxicology, University of Veterinary Medicine
Wentian Yang: Department of Orthopaedics, Rhode Island Hospital and Brown University Alpert Medical School
Eric Vivier: Centre d’Immunologie de Marseille-Luminy, Aix Marseille Université, Inserm, CNRS, Avenue de Luminy
Ping-Chih Ho: Department of Oncology UNIL CHUV, University of Lausanne
Laurent Brossay: Department of Molecular Microbiology and Immunology and Graduate Program in Pathobiology, Division of Biology and Medicine, Brown University Alpert Medical School
Greta Guarda: Department of Biochemistry, University of Lausanne

DOI: https://doi.org/10.1038/s41467-019-09431-3
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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The phosphatase Shp-2 was implicated in NK cell education due to its reported association with inhibitory receptors, but its function in this context is unclear. Here the authors show that Shp-2 is not required for NK cell function, but is necessary for IL-15-induced metabolic burst and expansion.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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