Glomerular Diseases Associated with Hepatitis C Virus Infection

Abstract

Renal diseases associated with hepatitis C virus (HCV) infection are a significant problem for clinicians and diagnostic pathologists. A wide variety of disorders, including a spectrum of immune-complex glomerulonephritides, has been reported in association with hepatitis and cirrhosis caused by HCV. For some of these diseases, including membranoproliferative glomerulonephritis type I and cryoglobulinemic glomerulonephritis, plausible links between HCV and the glomerular pathology have been proposed. In other cases, the role of the virus in the pathogenesis of the renal disease is less certain. This communication catalogues the renal manifestations of HCV infection, providing clinical and pathological descriptions of the most prevalent disorders. Where available, evidence implicating HCV in the causation of the disorders is also discussed.

Keywords

• Glomerulonephritis
• Hepatitis C virus
• Cryoglobulinemia
• Membranoproliferative glomerulonephritis
• Membranous glomerulonephritis.