Nature Communications (Nov 2016)

Acetylation of histone H4 lysine 5 and 12 is required for CENP-A deposition into centromeres

  • Wei-Hao Shang,
  • Tetsuya Hori,
  • Frederick G. Westhorpe,
  • Kristina M. Godek,
  • Atsushi Toyoda,
  • Sadahiko Misu,
  • Norikazu Monma,
  • Kazuho Ikeo,
  • Christopher W. Carroll,
  • Yasunari Takami,
  • Asao Fujiyama,
  • Hiroshi Kimura,
  • Aaron F. Straight,
  • Tatsuo Fukagawa

DOI
https://doi.org/10.1038/ncomms13465
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 13

Abstract

Read online

The deposition of histone H3 variant CENP-A bound with histone H4 is a key feature designating the centromere region of a chromosome. Here the authors show acetylation on residues K5 and K12 in histone H4, mediated by the RbAp46/48-Hat1 complex, is required for deposition of CENP-A-H4 into centromeres.