Nature Communications (Dec 2020)
Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma
- Yan Zhou,
- Dong Yang,
- Qingcheng Yang,
- Xiaobin Lv,
- Wentao Huang,
- Zhenhua Zhou,
- Yaling Wang,
- Zhichang Zhang,
- Ting Yuan,
- Xiaomin Ding,
- Lina Tang,
- Jianjun Zhang,
- Junyi Yin,
- Yujing Huang,
- Wenxi Yu,
- Yonggang Wang,
- Chenliang Zhou,
- Yang Su,
- Aina He,
- Yuanjue Sun,
- Zan Shen,
- Binzhi Qian,
- Wei Meng,
- Jia Fei,
- Yang Yao,
- Xinghua Pan,
- Peizhan Chen,
- Haiyan Hu
Affiliations
- Yan Zhou
- Oncology Department of Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Dong Yang
- Orthopaedic Department of Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Qingcheng Yang
- Orthopaedic Department of Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Xiaobin Lv
- Central Laboratory of the First Hospital of Nanchang
- Wentao Huang
- Pathology Department of Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Zhenhua Zhou
- Department of Orthopedic Oncology, Changzheng Hospital of Naval Military Medical University
- Yaling Wang
- Oncology Department of Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Zhichang Zhang
- Orthopaedic Department of Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Ting Yuan
- Orthopaedic Department of Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Xiaomin Ding
- Oncology Department of Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Lina Tang
- Oncology Department of Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Jianjun Zhang
- Oncology Department of Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Junyi Yin
- Oncology Department of Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Yujing Huang
- Oncology Department of Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Wenxi Yu
- Oncology Department of Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Yonggang Wang
- Oncology Department of Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Chenliang Zhou
- Oncology Department of Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Yang Su
- Oncology Department of Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Aina He
- Oncology Department of Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Yuanjue Sun
- Oncology Department of Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Zan Shen
- Oncology Department of Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Binzhi Qian
- MRC Centre for Reproductive Health & Edinburgh Cancer Research UK Centre, Queen’s Medical Research Institute
- Wei Meng
- Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University
- Jia Fei
- Department of Biochemistry and Molecular Biology, Medical College of Jinan University
- Yang Yao
- Oncology Department of Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Xinghua Pan
- Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University
- Peizhan Chen
- Clinical Research Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Haiyan Hu
- Oncology Department of Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- DOI
- https://doi.org/10.1038/s41467-020-20059-6
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
Osteosarcomas are difficult to treat and have a limited response to immunotherapy. Here, the authors analyse osteosarcomas at the single-cell level, and identify both the transdifferentiation of malignant cells and an array of immune cells that could have implications for metastasis and immunotherapy.
