Nature Communications (Jan 2021)
Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice
- Nikos E. Papaioannou,
- Natallia Salei,
- Stephan Rambichler,
- Kaushikk Ravi,
- Jelena Popovic,
- Vanessa Küntzel,
- Christian H. K. Lehmann,
- Remi Fiancette,
- Johanna Salvermoser,
- Dominika W. Gajdasik,
- Ramona Mettler,
- Denise Messerer,
- Joana Carrelha,
- Caspar Ohnmacht,
- Dirk Haller,
- Ralf Stumm,
- Tobias Straub,
- Sten Eirik W. Jacobsen,
- Christian Schulz,
- David R. Withers,
- Gunnar Schotta,
- Diana Dudziak,
- Barbara U. Schraml
Affiliations
- Nikos E. Papaioannou
- Faculty of Medicine, Biomedical Center, Institute for Cardiovascular Physiology and Pathophysiology, LMU Munich
- Natallia Salei
- Faculty of Medicine, Biomedical Center, Institute for Cardiovascular Physiology and Pathophysiology, LMU Munich
- Stephan Rambichler
- Faculty of Medicine, Biomedical Center, Institute for Cardiovascular Physiology and Pathophysiology, LMU Munich
- Kaushikk Ravi
- Faculty of Medicine, Biomedical Center, Institute for Cardiovascular Physiology and Pathophysiology, LMU Munich
- Jelena Popovic
- Faculty of Medicine, Biomedical Center, Institute for Cardiovascular Physiology and Pathophysiology, LMU Munich
- Vanessa Küntzel
- Faculty of Medicine, Biomedical Center, Institute for Cardiovascular Physiology and Pathophysiology, LMU Munich
- Christian H. K. Lehmann
- Laboratory of Dendritic Cell Biology, Department of Dermatology, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nürnberg
- Remi Fiancette
- Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham
- Johanna Salvermoser
- Faculty of Medicine, Biomedical Center, Institute for Cardiovascular Physiology and Pathophysiology, LMU Munich
- Dominika W. Gajdasik
- Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham
- Ramona Mettler
- Faculty of Medicine, Biomedical Center, Institute for Cardiovascular Physiology and Pathophysiology, LMU Munich
- Denise Messerer
- Medizinische Klinik und Poliklinik I, University Hospital Munich, LMU Munich
- Joana Carrelha
- Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford
- Caspar Ohnmacht
- Center of Allergy and Environment, Helmholtz Center and Technical University of Munich
- Dirk Haller
- ZIEL–Institute for Food and Health, Technische Universität München
- Ralf Stumm
- Institute of Pharmacology and Toxicology, Jena University Hospital
- Tobias Straub
- Core Facility Bioinformatics, Biomedical Center, LMU Munich
- Sten Eirik W. Jacobsen
- Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford
- Christian Schulz
- Medizinische Klinik und Poliklinik I, University Hospital Munich, LMU Munich
- David R. Withers
- Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham
- Gunnar Schotta
- Faculty of Medicine, Center for Integrated Protein Science Munich, LMU Munich
- Diana Dudziak
- Laboratory of Dendritic Cell Biology, Department of Dermatology, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nürnberg
- Barbara U. Schraml
- Faculty of Medicine, Biomedical Center, Institute for Cardiovascular Physiology and Pathophysiology, LMU Munich
- DOI
- https://doi.org/10.1038/s41467-020-20659-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 20
Abstract
Type 2 conventional dendritic cells (cDC2) are important immune activators in adults, but their development and functions at the neonatal stage remain unclear. Here the authors show, using fate-mapping and single-cell RNA sequencing, that neonatal cDC2 come from multiple origins, but converge functionally as potent immune activators upon proper stimuli.
