Nature Communications (Sep 2020)
Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis
- Frank Penkava,
- Martin Del Castillo Velasco-Herrera,
- Matthew D. Young,
- Nicole Yager,
- Lilian N. Nwosu,
- Arthur G. Pratt,
- Alicia Lledo Lara,
- Charlotte Guzzo,
- Ash Maroof,
- Lira Mamanova,
- Suzanne Cole,
- Mirjana Efremova,
- Davide Simone,
- Andrew Filer,
- Chrysothemis C. Brown,
- Andrew L. Croxford,
- John D. Isaacs,
- Sarah Teichmann,
- Paul Bowness,
- Sam Behjati,
- M. Hussein Al-Mossawi
Affiliations
- Frank Penkava
- Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford
- Martin Del Castillo Velasco-Herrera
- Wellcome Sanger Institute
- Matthew D. Young
- Wellcome Sanger Institute
- Nicole Yager
- Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford
- Lilian N. Nwosu
- Translational and Clinical Research Institute, Newcastle University
- Arthur G. Pratt
- Translational and Clinical Research Institute, Newcastle University
- Alicia Lledo Lara
- Wellcome Centre for Human Genetics, University of Oxford
- Charlotte Guzzo
- Wellcome Sanger Institute
- Ash Maroof
- UCB Pharma
- Lira Mamanova
- Wellcome Sanger Institute
- Suzanne Cole
- UCB Pharma
- Mirjana Efremova
- Wellcome Sanger Institute
- Davide Simone
- Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford
- Andrew Filer
- NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Institute of Inflammation and Ageing
- Chrysothemis C. Brown
- Infection, Inflammation and Rheumatology Section, UCL Great Ormond Street Institute of Child Health
- Andrew L. Croxford
- Idorsia Pharmaceuticals Ltd., Drug Discovery Immunology
- John D. Isaacs
- Translational and Clinical Research Institute, Newcastle University
- Sarah Teichmann
- Wellcome Sanger Institute
- Paul Bowness
- Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford
- Sam Behjati
- Wellcome Sanger Institute
- M. Hussein Al-Mossawi
- Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford
- DOI
- https://doi.org/10.1038/s41467-020-18513-6
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
Psoriatic arthritis (PsA) commonly affects patients with skin psoriasis, but its pathogenesis is still unclear. Here the authors use two types of single-cells data, mass cytometry and RNA sequencing, to describe the expansion and diversity of synovial, but not peripheral blood, CD8 T cells from PsA patients to provide a molecular immune landscape for PsA.
