Differential toxicity to murine small and large intestinal epithelium induced by oncology drugs

Jake M. Bieber; Laura E. Sanman; Xiaoxiao Sun; Heinz Hammerlindl; Feng Bao; Maike A. Roth; Megan L. Koleske; Liusheng Huang; Fran Aweeka; Lani F. Wu; Steven J. Altschuler

doi:10.1038/s42003-022-03048-x

Communications Biology (Jan 2022)

Differential toxicity to murine small and large intestinal epithelium induced by oncology drugs

Jake M. Bieber,
Laura E. Sanman,
Xiaoxiao Sun,
Heinz Hammerlindl,
Feng Bao,
Maike A. Roth,
Megan L. Koleske,
Liusheng Huang,
Fran Aweeka,
Lani F. Wu,
Steven J. Altschuler

Affiliations

Jake M. Bieber: Department of Pharmaceutical Chemistry, University of California, San Francisco
Laura E. Sanman: Department of Pharmaceutical Chemistry, University of California, San Francisco
Xiaoxiao Sun: Department of Pharmaceutical Chemistry, University of California, San Francisco
Heinz Hammerlindl: Department of Pharmaceutical Chemistry, University of California, San Francisco
Feng Bao: Department of Pharmaceutical Chemistry, University of California, San Francisco
Maike A. Roth: Department of Pharmaceutical Chemistry, University of California, San Francisco
Megan L. Koleske: Department of Bioengineering and Therapeutics, University of California, San Francisco
Liusheng Huang: Drug Research Unit, Department of Clinical Pharmacology, University of California, San Francisco
Fran Aweeka: Drug Research Unit, Department of Clinical Pharmacology, University of California, San Francisco
Lani F. Wu: Department of Pharmaceutical Chemistry, University of California, San Francisco
Steven J. Altschuler: Department of Pharmaceutical Chemistry, University of California, San Francisco

DOI: https://doi.org/10.1038/s42003-022-03048-x
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 11

Abstract

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Bieber et al use intestinal monolayers derived from fresh murine crypts as a model system to study drug toxicity. Testing 48 oncology drugs with known gastrointestinal toxicity as a proof of concept, they discover differential responses in cells from large and small intestine, increasing our mechanistic understanding of intestinal drug toxicity.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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