Pharmacogenomics and Personalized Medicine (Nov 2020)

P2RX7 Gene rs1718125 Polymorphism is Related with Postoperative Pain and Fentanyl Intake in Esophageal Cancer Patients

  • Zheng C,
  • Wang J,
  • Xie S

Journal volume & issue
Vol. Volume 13
pp. 585 – 589

Abstract

Read online

Cuijuan Zheng,1 Jiayu Wang,1 Shouxiang Xie2 1Department of Anesthesiology, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huaian, Jiangsu, People’s Republic of China; 2Department of Emergency, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huaian, Jiangsu, People’s Republic of ChinaCorrespondence: Shouxiang Xie Tel/Fax +86-517-80878245Email [email protected]: Prevention and control of postoperative pains are essential, which affects the prognosis and life quality of patients. Fentanyl is a widely used opioid drug for pre-, intra- and postoperative analgesia. Identifying a patient’s genotype before surgery may help to control the fentanyl dose in the perioperative period.Patients and Methods: This study enrolling 645 esophageal cancer (EC) patients was aimed to investigate the associations of P2RX7 gene rs1718125 polymorphism with fentanyl intake and postoperative pains in a Chinese Han population. Genotyping was accomplished by direct sequencing and polymerase chain reaction.Results: The GA/AA genotype carriers showed lower visual analog scale scores at postoperative 0, 6 and 24 h, but not at 48 h, compared with the GG genotype. The fentanyl consumption of GG genotype was remarkably more relative to the GA/AA genotype at 6 and 24 h after treatment.Conclusion: P2RX7 rs1718125 polymorphism is connected to the postoperative pains and fentanyl use for EC patients.Keywords: esophageal cancer, fentanyl, P2RX7, single nucleotide polymorphism, postoperative pain

Keywords