Toxic pathological effect of mitomycin-c on male reproductive organs in rat

Abstract

The aim of the present study has detected the effect of Mitomycin-c on the histological structure on a male reproductive organ. In this study used (24) healthy adult male rats were divided into three groups, each group includes (8) animals: the 1st toxic group was injected (6.5mg/kg) of Mitomycin-c subcutaneous (s/c) once daily, the 2ed therapeutic or low dose group was injected (3.25 mg/kg) of Mitomycin-c subcutaneous (s/c) once daily, while the 3rd control group was injected physiological normal saline (0.9% NaCl2). The experimental period was (10) weeks. Animal, which was treated with Mitomycin-c along the period of the experiment showed, severe pathological changes, particularly in testes and epididymis.