Nutrients (Dec 2020)
Quality of Life in Women Diagnosed with Breast Cancer after a 12-Month Treatment of Lifestyle Modifications
- Concetta Montagnese,
- Giuseppe Porciello,
- Sara Vitale,
- Elvira Palumbo,
- Anna Crispo,
- Maria Grimaldi,
- Ilaria Calabrese,
- Rosa Pica,
- Melania Prete,
- Luca Falzone,
- Massimo Libra,
- Serena Cubisino,
- Luigina Poletto,
- Valentina Martinuzzo,
- Sergio Coluccia,
- Nadia Esindi,
- Flavia Nocerino,
- Anita Minopoli,
- Bruna Grilli,
- Pasqualina C. Fiorillo,
- Marco Cuomo,
- Ernesta Cavalcanti,
- Guglielmo Thomas,
- Daniela Cianniello,
- Monica Pinto,
- Michelino De Laurentiis,
- Carmen Pacilio,
- Massimo Rinaldo,
- Massimiliano D'Aiuto,
- Diego Serraino,
- Samuele Massarut,
- Laura Caggiari,
- Chiara Evangelista,
- Agostino Steffan,
- Francesca Catalano,
- Giuseppe L. Banna,
- Giuseppa Scandurra,
- Francesco Ferraù,
- Rosalba Rossello,
- Giovanna Antonelli,
- Gennaro Guerra,
- Amalia Farina,
- Francesco Messina,
- Gabriele Riccardi,
- Davide Gatti,
- David J. A. Jenkins,
- Egidio Celentano,
- Gerardo Botti,
- Livia S. A. Augustin
Affiliations
- Concetta Montagnese
- Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori—IRCCS “Fondazione G. Pascale”, 80131 Napoli, Italy
- Giuseppe Porciello
- Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori—IRCCS “Fondazione G. Pascale”, 80131 Napoli, Italy
- Sara Vitale
- Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori—IRCCS “Fondazione G. Pascale”, 80131 Napoli, Italy
- Elvira Palumbo
- Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori—IRCCS “Fondazione G. Pascale”, 80131 Napoli, Italy
- Anna Crispo
- Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori—IRCCS “Fondazione G. Pascale”, 80131 Napoli, Italy
- Maria Grimaldi
- Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori—IRCCS “Fondazione G. Pascale”, 80131 Napoli, Italy
- Ilaria Calabrese
- Department of Clinical Medicine and Surgery, Federico II University, 80131 Napoli, Italy
- Rosa Pica
- Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori—IRCCS “Fondazione G. Pascale”, 80131 Napoli, Italy
- Melania Prete
- Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori—IRCCS “Fondazione G. Pascale”, 80131 Napoli, Italy
- Luca Falzone
- Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori—IRCCS “Fondazione G. Pascale”, 80131 Napoli, Italy
- Massimo Libra
- Department of Biomedical and Biotechnological Sciences Oncologic, Clinical and General Pathology Section, University of Catania, 95131 Catania, Italy
- Serena Cubisino
- Cannizzaro Hospital, 95126 Catania, Italy
- Luigina Poletto
- Cancer Epidemiology Unit, National Cancer Institute Centro di Riferimento Oncologico, IRCCS, 33081 Aviano, Italy
- Valentina Martinuzzo
- Cancer Epidemiology Unit, National Cancer Institute Centro di Riferimento Oncologico, IRCCS, 33081 Aviano, Italy
- Sergio Coluccia
- Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori—IRCCS “Fondazione G. Pascale”, 80131 Napoli, Italy
- Nadia Esindi
- School of Life and Environmental Sciences and Charles Perkins Centre, University of Sydney, Sydney 2006, Australia
- Flavia Nocerino
- Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori—IRCCS “Fondazione G. Pascale”, 80131 Napoli, Italy
- Anita Minopoli
- Laboratory Medicine Unit, Istituto Nazionale Tumori—IRCCS “Fondazione G. Pascale”, 80131 Napoli, Italy
- Bruna Grilli
- Laboratory Medicine Unit, Istituto Nazionale Tumori—IRCCS “Fondazione G. Pascale”, 80131 Napoli, Italy
- Pasqualina C. Fiorillo
- Laboratory Medicine Unit, Istituto Nazionale Tumori—IRCCS “Fondazione G. Pascale”, 80131 Napoli, Italy
- Marco Cuomo
- Laboratory Medicine Unit, Istituto Nazionale Tumori—IRCCS “Fondazione G. Pascale”, 80131 Napoli, Italy
- Ernesta Cavalcanti
- Laboratory Medicine Unit, Istituto Nazionale Tumori—IRCCS “Fondazione G. Pascale”, 80131 Napoli, Italy
- Guglielmo Thomas
- Clinica Mediterranea, 80122 Napoli, Italy
- Daniela Cianniello
- Division of Breast Oncology, Istituto Nazionale Tumori—IRCCS “Fondazione G. Pascale”, 80131 Napoli, Italy
- Monica Pinto
- Rehabilitation Medicine Unit, Istituto Nazionale Tumori—IRCCS “Fondazione G. Pascale”, 80131 Napoli, Italy
- Michelino De Laurentiis
- Division of Breast Oncology, Istituto Nazionale Tumori—IRCCS “Fondazione G. Pascale”, 80131 Napoli, Italy
- Carmen Pacilio
- Division of Breast Oncology, Istituto Nazionale Tumori—IRCCS “Fondazione G. Pascale”, 80131 Napoli, Italy
- Massimo Rinaldo
- Division of Breast Oncology, Istituto Nazionale Tumori—IRCCS “Fondazione G. Pascale”, 80131 Napoli, Italy
- Massimiliano D'Aiuto
- Clinica Villa Fiorita, Aversa 81031, Italy
- Diego Serraino
- Cancer Epidemiology Unit, National Cancer Institute Centro di Riferimento Oncologico, IRCCS, 33081 Aviano, Italy
- Samuele Massarut
- Cancer Epidemiology Unit, National Cancer Institute Centro di Riferimento Oncologico, IRCCS, 33081 Aviano, Italy
- Laura Caggiari
- Immunopathology and Cancer Biomarkers Unit, National Cancer Institute Centro di Riferimento Oncologico, IRCCS, 33081 Aviano, Italy
- Chiara Evangelista
- Immunopathology and Cancer Biomarkers Unit, National Cancer Institute Centro di Riferimento Oncologico, IRCCS, 33081 Aviano, Italy
- Agostino Steffan
- Immunopathology and Cancer Biomarkers Unit, National Cancer Institute Centro di Riferimento Oncologico, IRCCS, 33081 Aviano, Italy
- Francesca Catalano
- Cannizzaro Hospital, 95126 Catania, Italy
- Giuseppe L. Banna
- Cannizzaro Hospital, 95126 Catania, Italy
- Giuseppa Scandurra
- Cannizzaro Hospital, 95126 Catania, Italy
- Francesco Ferraù
- Ospedale San Vincenzo, 98039 Taormina, Italy
- Rosalba Rossello
- Ospedale San Vincenzo, 98039 Taormina, Italy
- Giovanna Antonelli
- Ospedale San Vincenzo, 98039 Taormina, Italy
- Gennaro Guerra
- Ospedale Evangelico Betania, 80147 Napoli, Italy
- Amalia Farina
- Ospedale Evangelico Betania, 80147 Napoli, Italy
- Francesco Messina
- Ospedale Evangelico Betania, 80147 Napoli, Italy
- Gabriele Riccardi
- Department of Clinical Medicine and Surgery, Federico II University, 80131 Napoli, Italy
- Davide Gatti
- Rheumatology Unit, University of Verona, 37129 Verona, Italy
- David J. A. Jenkins
- Departments of Nutritional Sciences and Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, ON M5S, Canada
- Egidio Celentano
- Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori—IRCCS “Fondazione G. Pascale”, 80131 Napoli, Italy
- Gerardo Botti
- Scientific Directorate, Istituto Nazionale Tumori—IRCCS “Fondazione G. Pascale”, 80131 Napoli, Italy
- Livia S. A. Augustin
- Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori—IRCCS “Fondazione G. Pascale”, 80131 Napoli, Italy
- DOI
- https://doi.org/10.3390/nu13010136
- Journal volume & issue
-
Vol. 13,
no. 1
p. 136
Abstract
Healthy lifestyles are associated with better health-related quality of life (HRQoL), favorable prognosis and lower mortality in breast cancer (BC) survivors. We investigated changes in HRQoL after a 12-month lifestyle modification program in 227 BC survivors participating in DEDiCa trial (Mediterranean diet, exercise, vitamin D). HRQoL was evaluated through validated questionnaires: EQ-5D-3L, EORTC-QLQ-C30 and EORTC QLQ-BR23. Baseline changes were tested using analysis of variance. Multiple regression analyses were performed to assess treatment effects on HRQoL. Increases were observed in global health status (p p = 0.003), role (p = 0.002) and social functioning (p p p p = 0.001), and reductions in fatigue (p p = 0.015), dyspnea (p = 0.001), constipation (p = 0.049), financial problems (p = 0.012), sexual functioning (p = 0.025), systematic therapy side effects (p p = 0.004). Multiple regression analyses found inverse associations between changes in BMI and global health status (p = 0.048) and between serum 25(OH)D levels and breast symptoms (p = 0.002). A healthy lifestyle treatment of traditional Mediterranean diet and exercise may impact positively on HRQoL in BC survivors possibly through reductions in body weight while vitamin D sufficiency may improve BC-related symptoms. These findings are relevant to BC survivors whose lower HRQoL negatively affects treatment compliance and disease outcomes.
Keywords