Generation of two NAGLU-mutated homozygous cell lines from healthy induced pluripotent stem cells using CRISPR/Cas9 to model Sanfilippo B syndrome

• Noelia Benetó,
• Monica Cozar,
• Laura Gort,
• Laura Pacheco,
• Lluïsa Vilageliu,
• Daniel Grinberg,
• Isaac Canals

Affiliations

Noelia Benetó

Department of Genetics, Microbiology and Statistics, Fac. Biology, University of Barcelona, CIBERER, IBUB, IRSJD, Spain

Monica Cozar

Department of Genetics, Microbiology and Statistics, Fac. Biology, University of Barcelona, CIBERER, IBUB, IRSJD, Spain

Laura Gort

Secció d'Errors Congènits del Metabolisme -IBC, Servei de Bioquímica i Genètica Molecular, Hospital Clínic, IDIBAPS, CIBERER, Barcelona, Spain

Laura Pacheco

Secció d'Errors Congènits del Metabolisme -IBC, Servei de Bioquímica i Genètica Molecular, Hospital Clínic, IDIBAPS, CIBERER, Barcelona, Spain

Lluïsa Vilageliu

Department of Genetics, Microbiology and Statistics, Fac. Biology, University of Barcelona, CIBERER, IBUB, IRSJD, Spain

Daniel Grinberg

Department of Genetics, Microbiology and Statistics, Fac. Biology, University of Barcelona, CIBERER, IBUB, IRSJD, Spain; Corresponding authors.

Isaac Canals

Stem Cells, Aging and Neurodegeneration Group, Lund Stem Cell Center, University Hospital, Lund, Sweden; Corresponding authors.