Seipin and the membrane-shaping protein Pex30 cooperate in organelle budding from the endoplasmic reticulum

Sihui Wang; Fatima-Zahra Idrissi; Martin Hermansson; Alexandra Grippa; Christer S. Ejsing; Pedro Carvalho

doi:10.1038/s41467-018-05278-2

Nature Communications (Jul 2018)

Seipin and the membrane-shaping protein Pex30 cooperate in organelle budding from the endoplasmic reticulum

Sihui Wang,
Fatima-Zahra Idrissi,
Martin Hermansson,
Alexandra Grippa,
Christer S. Ejsing,
Pedro Carvalho

Affiliations

Sihui Wang: Sir William Dunn School of Pathology, University of Oxford
Fatima-Zahra Idrissi: Cell and Developmental Biology Programme, Centre for Genomic Regulation (CRG)
Martin Hermansson: Department of Biochemistry and Molecular Biology, Villum Center for Bioanalytical Sciences, University of Southern Denmark
Alexandra Grippa: Cell and Developmental Biology Programme, Centre for Genomic Regulation (CRG)
Christer S. Ejsing: Department of Biochemistry and Molecular Biology, Villum Center for Bioanalytical Sciences, University of Southern Denmark
Pedro Carvalho: Sir William Dunn School of Pathology, University of Oxford

DOI: https://doi.org/10.1038/s41467-018-05278-2
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

Read online

Lipid droplets (LDs) and peroxisomes both emerge from the endoplasmic reticulum (ER). Here, the authors show that yeast Seipin and Pex30 proteins act together to regulate budding of these organelles from the same subdomain of the ER.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal