Nature Communications (Mar 2018)

Gene-by-environment interactions in urban populations modulate risk phenotypes

  • Marie-Julie Favé,
  • Fabien C. Lamaze,
  • David Soave,
  • Alan Hodgkinson,
  • Héloïse Gauvin,
  • Vanessa Bruat,
  • Jean-Christophe Grenier,
  • Elias Gbeha,
  • Kimberly Skead,
  • Audrey Smargiassi,
  • Markey Johnson,
  • Youssef Idaghdour,
  • Philip Awadalla

DOI
https://doi.org/10.1038/s41467-018-03202-2
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

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Individuals with different genotypes may respond differently to environmental variation. Here, Favé et al. find substantial impacts of different environment exposures on the transcriptome and clinical endophenotypes when controlling for genetic ancestry by analyzing data from ∼1000 individuals from a founder population in Quebec.