Journal of Inflammation Research (Aug 2021)
The Promoting Effect of Traumatic Brain Injury on the Incidence and Progression of Glioma: A Review of Clinical and Experimental Research
Abstract
Yu-Long Lan,1– 3 Yongjian Zhu,1 Gao Chen,1 Jianmin Zhang1 1Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China; 2Department of Neurosurgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, People’s Republic of China; 3Department of Neurosurgery, Shenzhen People’s Hospital, Shenzhen, People’s Republic of ChinaCorrespondence: Yu-Long LanDepartment of Neurosurgery, Second Affiliated Hospital, School of medicine, Zhejiang University, Hangzhou, 310000, People’s Republic of ChinaTel +86 18858195203Email [email protected] ZhangDepartment of Neurosurgery, Second Affiliated Hospital, School of medicine, Zhejiang University, Hangzhou, 310000, People’s Republic of ChinaTel +86 13805722695Email [email protected]: The role of traumatic brain injury in the development of glioma is highly controversial since first presented. This is not unexpected because traumatic brain injuries are overwhelmingly more common than glioma. However, the causes of post-traumatic glioma have been long discussed and still warrant further research. In this review, we have presented an overview of previous cohort studies and case–control studies. We have summarized the roles of microglial cells, macrophages, astrocytes, and stem cells in post-traumatic glioma formation and development, and reviewed various carcinogenic factors involved during traumatic brain injury, especially those reported in experimental studies indicating a relationship with glioma progression. Besides, traumatic brain injury and glioma share several common pathways, including inflammation and oxidative stress; however, the exact mechanism underlying this co-occurrence is yet to be discovered. In this review, we have summarized current epidemiological studies, clinical reports, pathophysiological research, as well as investigations evaluating the probable causes of co-occurrence and treatment possibilities. More efforts should be directed toward elucidating the relationship between traumatic brain injury and glioma, which could likely lead to promising pharmacological interventions towards designing therapeutic strategies.Keywords: traumatic brain injury, glioma, promotion, mechanism
