Evaluation of High-Sensitivity C-Reactive Protein and Irisin in Saliva and Serum of Patients with Myocardial Infarction

Abstract

Introduction: Cardiovascular diseases are the leading cause of mortality worldwide. Despite the importance of early diagnosis and advances in medicine, one-third of Myocardial Infarction (MI) cases remain undiagnosed. Biomarkers are a reflection of the physiologic function and pathologic changes in the body. Saliva is a refined plasma that can replace blood to facilitate and accelerate the diagnosis process given the benefits of its collection and storage. The present study aimed to investigate the correlation between serum and saliva hs-CRP and Irisin concentration in MI patients.Materials and Methods: In this case-control study, 46 cases were selected including 24 acute MI and 22 controls. The serum and saliva samples were collected and the amount of Irisin and hs-CRP was measured in each sample in the specialized biochemistry laboratory of Mashhad Medical School. Data were analyzed using SPSS (version 22) by Pearson correlation coefficient test (P<0.05).Results: The concentration of Saliva Irisin was significantly lower in the patient group than that in the control group (P=0.021). The levels of serum and salivary hs-CRP were significantly higher in the patient group than those in the control group (for both P<0.001). The concentration of marker in saliva significantly increased as the concentration of marker increased in serum (P<0.001).Conclusion: Measurement and reduction of salivary Irisin concentrations can be a reliable criterion for diagnosing and predicting MI. The concentration of hs-CRP in saliva and serum is directly related to MI.

Keywords

• biomarkers
• c-reactive protein
• irisin
• myocardial infarction
• saliva
• serum