#299 : Sex Ratio in Children Born After Assisted Reproduction and After Spontaneous Conception in the Czech Republic

Abstract

Background and Aims: Various authors described slight differences in the sex ratio in the children born after the use of various assisted reproduction techniques (ART). Our goal was to investigate this trend using population-wide datasets from the official medical registries of the Czech Republic. Method: We have used data from the official medical registries run by the Institute of Health Information and Statistics of the Czech Republic, namely the National Registry of Congenital Anomalies and the National Registry of Assisted Reproduction. The registration process in the Czech Republic is population-wide and the reporting is compulsory by the national law. We analyzed the number of births of children depending on the method of conception, the presence of a congenital defect, the twinning rate, and maternal age. Study period: 2013–2020. Results: A total of 881,975 children were born in the study period, 853,131 were born after spontaneous conception, and 28,844 after ART. The frequency of males was 50,89% in the spontaneously conceived children and 50.3% in the ART-conceived children, but the difference is not statistically significant. Among the children born with some kind of congenital anomaly, the males were more frequent, but again the difference was not statistically significant. Analyzing the different subgroups according to the twinning rate also did not identify any statistically significant trend. Conclusion: Using the population-wide data we have confirmed changes in the sex ratio in children born after ART conception (especially analyzing different study subgroups according to the presence/absence of congenital anomaly and according to the twinning rate). None of the trends was classified as statistically significant. Supported by Ministry of Health, Czech Republic – conceptual development of research organization (Thomayer University Hospital - TUH, 00064190)