Eunicellin-Based Diterpenoids, Hirsutalins S–V, from the Formosan Soft Coral Cladiella hirsuta
Tzu-Zin Huang,
Bo-Wei Chen,
Chiung-Yao Huang,
Tsong-Long Hwang,
Chokkalingam Uvarani,
Chang-Feng Dai,
Ping-Jyun Sung,
Jui-Hsin Su,
Jyh-Horng Sheu
Affiliations
Tzu-Zin Huang
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Bo-Wei Chen
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Chiung-Yao Huang
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Tsong-Long Hwang
Graduate Institute of Natural Products, School of Traditional Chinese Medicine, College of Medicine, and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan
Chokkalingam Uvarani
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Chang-Feng Dai
Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan
Ping-Jyun Sung
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Jui-Hsin Su
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Jyh-Horng Sheu
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Four new eunicellin-type hirsutalins S–V (1–4), along with a known compound (–)-6α-hydroxy polyanthellin A (5), were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxity of compounds 1–5 against the proliferation of a limited panel of cancer cell lines was measured. Anti-inflammatory activity of compounds 1–5 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/ CB-induced human neutrophils.
