Biomimetic and Materials-Potentiated Cell Engineering for Cancer Immunotherapy
Tingting Zhang,
Yushan Yang,
Li Huang,
Ying Liu,
Gaowei Chong,
Weimin Yin,
Haiqing Dong,
Yan Li,
Yongyong Li
Affiliations
Tingting Zhang
Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200092, China
Yushan Yang
Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200092, China
Li Huang
Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200092, China
Ying Liu
Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200092, China
Gaowei Chong
Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200092, China
Weimin Yin
Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200092, China
Haiqing Dong
Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration, Ministry of Education, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200092, China
Yan Li
Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200092, China
Yongyong Li
Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200092, China
In cancer immunotherapy, immune cells are the main force for tumor eradication. However, they appear to be dysfunctional due to the taming of the tumor immunosuppressive microenvironment. Recently, many materials-engineered strategies are proposed to enhance the anti-tumor effect of immune cells. These strategies either utilize biomimetic materials, as building blocks to construct inanimate entities whose functions are similar to natural living cells, or engineer immune cells with functional materials, to potentiate their anti-tumor effects. In this review, we will summarize these advanced strategies in different cell types, as well as discussing the prospects of this field.