Vìsnik Dnìpropetrovsʹkogo Unìversitetu: Serìâ Hìmìâ (Mar 2014)

Sequential injection spectrophotometric determination of analgine in pharmaceutical formulations using 18-molybdo-2-phosphate heteropoly anion as chromogenic reagent

  • Mohammed Khair E. A. Al-Shwaiyat,
  • Andriy B. Vishnikin,
  • Ludmila P. Tsiganok,
  • Ekaterina V. Kabashnaya,
  • Svetlana A. Khmelovskaya,
  • Vasil Andruch,
  • Yaroslav R. Bazel,
  • Hana Sklenářová,
  • Petr Solich

DOI
https://doi.org/10.15421/081301
Journal volume & issue
Vol. 21, no. 19
pp. 7 – 19

Abstract

Read online

Simple, sensitive and selective sequential injection analysis (SIA) method for the analgine determination has been developed on the basis of fast reaction between analgine and 18-molybdo-2-phosphate heteropoly anion (18-MPA). Under found optimal conditions (0.01 M HCl, C(18-MPA) = 2 mmol/L) linear calibration curve was obtained over the range from 0.5 to 80 mg/L of analgine, and detection limit (S/N = 3) was 0.2 mg/L. The proposed SIA method has high sample throughput of 45 h-1 and small reagent consumption (0.08 mL). The procedure was successfully applied to the analysis of pharmaceuticals.

Keywords