A highly efficient eco-friendly AFO reaction using grinding technique: synthesis of 3-hydroxy-2-phenyl-4H-chromen-4-ones

Abstract

2′-Hydroxychalcones, on reaction with urea-hydrogen peroxide complex (UHP) and potassium hydroxide moist with ethanol, under grinding conditions, provided 3-hydroxy-2-phenyl-4H-chromen-4-ones (3-hydroxyflavones or flavonols) in excellent yields. Epoxidation followed by oxidative cyclization takes place simultaneously in a single pot reaction.

Keywords

• 2′-hydroxychalcones
• alkaline medium
• eco-friendly
• grinding technique
• urea-hydrogen peroxide complex (uhp)