USE OF THROMBIN GENERATION ASSAY FOR THE EVALUATION OF COAGULATION AND ANTICOAGULANT ACTIVITY OF HEMOSTASIS SYSTEM IN PATIENTS WITH ABDOMINAL SEPSIS

Abstract

Generally recognized factor, which complicates the course of sepsis, is the development of hypercoagulation syndrome. The increase of thrombin coagulation indicates on the elevation of risk of thrombus formation in microcirculation vessels, which could cause the formation of multiple organ failure. The thrombin generation assay is a new method of the evaluation of homeostasis system status. The test reflects the fermentation activity of thrombin and shows the functional condition, which arises in the interaction of procoagulant and anticoagulant. The diagnosis of generalized peritonitis had 30 patients (18 men and 12 women, aged 61±18,3 years) and they were included in the research. It was shown, that the use of thrombin generation assay in patients with the abdominal sepsis could give the well-timed analysis of hypercoagulation changes and the assessment of protein C system investment in the thrombin generation.

Keywords

• перитонит
• абдоминальный сепсис
• нарушения в системе гемостаза
• тест генерации тромбина
• вклад системы протеина с в угнетение генерации тромбина
• peritonitis
• abdominal sepsis
• dyscrasia
• thrombin generation assay
• protein c system investment in thrombin depression