Acta Biomedica Scientifica (Feb 2013)
Peculiarities of the organization of circadian rhythm of interhemispheric asymmetry in children and adolescents with essential arterial hypertension
Abstract
62 patients of 10—18 years (14,6 ± 2,1) with essential arterial hypertension duration of disease from 0 to 5 years were examined. Control group included. 62 almost healthy children who are compared to the children of main group by age and sex. Daily monitoring of arterial pressure during 24 hours with use of portable device for AP monitoring Oscar 2 for Medilog Prima system, was included in complex of examination of all the patients. During daily AP monitoring multiple neuropsychological testing was carried out. State of interhemispheric asymmetry in daily cycle was estimated. 3 times — in the morning with the beginning of daily monitoring, in the afternoon (6—7 p.m.) and next morning after night sleep (9—11 a.m.). Estimation of sensomotor asymmetry included manual, visual and. aural asymmetry and. also legs asymmetry. The research of peculiarities of organization of circadian rhythm of interhemispheric asymmetry in children and. teenagers with essential arterial hypertension showed, high lability of interhemispheric interrelations. At this fluctuation of lateral signs during 24 hours at multiple testing of oatients with arterial hypertension differed from the data of control group. Normally there was rotation of functional activity of left and. right hemispheres in "day — night" cycle and. at arterial hypertension this rhythm disappeared and primary prevalence of functional activity of right hemisphere appeared. In our opinion high lability of interhemispheric asymmetry and desynchronization of daily rhythm are the consequences of pathological changes connected with worsening of functional abilities of structures of left (dominant) hemisphere and. further rebuilding of integrative activity of central neural system. From the other hand high lability and weakly expressed interhemispheric asymmetry in combination with changes of circadian rhythms of interhemispheric interrelations in compensatory processes lighten more significant including of structures of left hemisphere in realization of cognitive activity. Consequently this condition of interhemispheric interrelations can be also compensatory mechanism capable to relieve correction of cognitive functions disordered as the result of the disease.
