Nature Communications (Dec 2020)
A human tissue map of 5-hydroxymethylcytosines exhibits tissue specificity through gene and enhancer modulation
- Xiao-Long Cui,
- Ji Nie,
- Jeremy Ku,
- Urszula Dougherty,
- Diana C. West-Szymanski,
- Francois Collin,
- Christopher K. Ellison,
- Laura Sieh,
- Yuhong Ning,
- Zifeng Deng,
- Carolyn W. T. Zhao,
- Anna Bergamaschi,
- Joel Pekow,
- Jiangbo Wei,
- Alana V. Beadell,
- Zhou Zhang,
- Geeta Sharma,
- Raman Talwar,
- Patrick Arensdorf,
- Jason Karpus,
- Ajay Goel,
- Marc Bissonnette,
- Wei Zhang,
- Samuel Levy,
- Chuan He
Affiliations
- Xiao-Long Cui
- Department of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, University of Chicago
- Ji Nie
- Department of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, University of Chicago
- Jeremy Ku
- Bluestar Genomics Inc.
- Urszula Dougherty
- Department of Medicine, University of Chicago
- Diana C. West-Szymanski
- Howard Hughes Medical Institute, University of Chicago
- Francois Collin
- Bluestar Genomics Inc.
- Christopher K. Ellison
- Bluestar Genomics Inc.
- Laura Sieh
- Department of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, University of Chicago
- Yuhong Ning
- Bluestar Genomics Inc.
- Zifeng Deng
- Department of Medicine, University of Chicago
- Carolyn W. T. Zhao
- Department of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, University of Chicago
- Anna Bergamaschi
- Bluestar Genomics Inc.
- Joel Pekow
- Department of Medicine, University of Chicago
- Jiangbo Wei
- Department of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, University of Chicago
- Alana V. Beadell
- Department of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, University of Chicago
- Zhou Zhang
- Department of Preventive Medicine, Northwestern University Feinberg School of Medicine
- Geeta Sharma
- City of Hope Comprehensive Cancer Center
- Raman Talwar
- Bluestar Genomics Inc.
- Patrick Arensdorf
- Bluestar Genomics Inc.
- Jason Karpus
- Department of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, University of Chicago
- Ajay Goel
- City of Hope Comprehensive Cancer Center
- Marc Bissonnette
- Department of Medicine, University of Chicago
- Wei Zhang
- Department of Preventive Medicine, Northwestern University Feinberg School of Medicine
- Samuel Levy
- Bluestar Genomics Inc.
- Chuan He
- Department of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, University of Chicago
- DOI
- https://doi.org/10.1038/s41467-020-20001-w
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
DNA 5-hydroxymethylcytosine (5hmC) modification is associated with gene transcription and used as a mark of mammalian development. Here the authors report a comprehensive 5hmC tissue map and analysis of 5hmC genomic distributions in 19 human tissues derived from 10 organ systems, thus providing insights into the role of 5hmC in tissue-specific development.
