Nature Communications (Apr 2021)
Proteomics of protein trafficking by in vivo tissue-specific labeling
- Ilia A. Droujinine,
- Amanda S. Meyer,
- Dan Wang,
- Namrata D. Udeshi,
- Yanhui Hu,
- David Rocco,
- Jill A. McMahon,
- Rui Yang,
- JinJin Guo,
- Luye Mu,
- Dominique K. Carey,
- Tanya Svinkina,
- Rebecca Zeng,
- Tess Branon,
- Areya Tabatabai,
- Justin A. Bosch,
- John M. Asara,
- Alice Y. Ting,
- Steven A. Carr,
- Andrew P. McMahon,
- Norbert Perrimon
Affiliations
- Ilia A. Droujinine
- Department of Genetics, Blavatnik Institute, Harvard Medical School
- Amanda S. Meyer
- Department of Stem Cell Biology and Regenerative Medicine, University of Southern California
- Dan Wang
- Department of Genetics, Blavatnik Institute, Harvard Medical School
- Namrata D. Udeshi
- Broad Institute of Harvard and MIT
- Yanhui Hu
- Department of Genetics, Blavatnik Institute, Harvard Medical School
- David Rocco
- Department of Genetics, Blavatnik Institute, Harvard Medical School
- Jill A. McMahon
- Department of Stem Cell Biology and Regenerative Medicine, University of Southern California
- Rui Yang
- Department of Stem Cell Biology and Regenerative Medicine, University of Southern California
- JinJin Guo
- Department of Stem Cell Biology and Regenerative Medicine, University of Southern California
- Luye Mu
- Department of Electrical Engineering, Yale University
- Dominique K. Carey
- Broad Institute of Harvard and MIT
- Tanya Svinkina
- Broad Institute of Harvard and MIT
- Rebecca Zeng
- Department of Genetics, Blavatnik Institute, Harvard Medical School
- Tess Branon
- Chan Zuckerberg Biohub
- Areya Tabatabai
- Department of Genetics, Blavatnik Institute, Harvard Medical School
- Justin A. Bosch
- Department of Genetics, Blavatnik Institute, Harvard Medical School
- John M. Asara
- Department of Medicine, Harvard Medical School
- Alice Y. Ting
- Chan Zuckerberg Biohub
- Steven A. Carr
- Broad Institute of Harvard and MIT
- Andrew P. McMahon
- Department of Stem Cell Biology and Regenerative Medicine, University of Southern California
- Norbert Perrimon
- Department of Genetics, Blavatnik Institute, Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-021-22599-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 22
Abstract
The network of proteins secreted for interorgan communication is poorly understood. Here, the authors develop a method, based on protein labeling, to study cell-specific secretomes and interorgan protein trafficking, and demonstrate their approach in Drosophila and mouse models.
